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As mentioned above, the link between TNF-α and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

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The first randomized control study describing the usefulness of this therapy was reported in 2016 by Larsen et al.55 Their results showed that treatment with high-volume PLEX improved the in-hospital survival rate without liver transplantation, compared with standard medical therapy (59 vs 48%, respectively